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Article

Early life adversity and cardiovascular responses to repeated stress among adolescents: Moderating role of COMT gene rs4680 polymorphism.

Psychoneuroendocrinology - 1 Apr 2023

Lü Wei, Ji Huayu, Li Yushan

Abstract excerpt

BACKGROUND: Early life adversity (ELA) increases the risk of cardiovascular diseases through dysregulation of cardiovascular stress responses manifested by either exaggerated or blunted reactivity. The catechol-O-methyltransferase (COMT) gene rs4680 polymorphism has been identified in gene-environment interaction (G×E) studies to explain individual differences in the effects of ELA on physiological stress...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36702041
DOI: 10.1016/j.psyneuen.2023.106029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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