Evolution of Rapid Clonal Dynamics and Non-Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer.

doi:10.1200/PO.23.00260

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Article

Evolution of Rapid Clonal Dynamics and Non-Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer.

JCO precision oncology - 1 Dec 2024

Simhadri Srilatha, Carrick Jillian N, Murphy Susan, Kothari Om A, Al-Hraishami Husam, Kulkarni Atul, Jalloul Nahed, Stefanik Katarina, Bandari Manisha, Chettur Kavya, Yao Ming, Ginjala Vasudeva, Groisberg Roman, Hochster Howard, Mehnert Janice, Riedlinger Gregory, Khiabanian Hossein, Verzi Michael P, Tong Kevin, Ganesan Shridar

Abstract excerpt

PURPOSE: Combined BRAF, MEK, and EGFR inhibition can induce clinical responses in BRAF-V600E-mutant colon cancer, but rapid resistance often occurs. METHODS: We use serial monitoring of circulating tumor DNA cell-free plasma DNA (cfDNA) in a patient case study in addition to organoids derived from mouse models of BRAF-V600E-mutant intestinal cancer, which emulated the patient's mutational profile to assess drug...

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PMID: 39626159
DOI: 10.1200/PO.23.00260
PMCID: PMC11627326

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