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Article

Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2015

Morelli M P, Overman M J, Dasari A, Kazmi S M A, Mazard T, Vilar E, Morris V K, Lee M S, Herron D, Eng C, Morris J, Kee B K, Janku F, Deaton F L, Garrett C, Maru D, Diehl F, Angenendt P, Kopetz S

Abstract excerpt

INTRODUCTION: KRAS and EGFR ectodomain-acquired mutations in patients with metastatic colorectal cancer (mCRC) have been correlated with acquired resistance to anti-EGFR monoclonal antibodies (mAbs). We investigated the frequency, co-occurrence, and distribution of acquired KRAS and EGFR mutation...

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Share to Clone Cells
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Staging

Share to Neoplastic Cells, Circulating

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

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Source

Open in PubMed Open full text

Identifiers

PMID: 25628445
DOI: 10.1093/annonc/mdv005
PMCID: PMC4374387

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25628445-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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