Article
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.
Nature medicine - 1 Jul 2015
Siravegna Giulia, Mussolin Benedetta, Buscarino Michela, Corti Giorgio, Cassingena Andrea, Crisafulli Giovanni, Ponzetti Agostino, Cremolini Chiara, Amatu Alessio, Lauricella Calogero, Lamba Simona, Hobor Sebastijan, Avallone Antonio, Valtorta Emanuele, Rospo Giuseppe, Medico Enzo, Motta Valentina, Antoniotti Carlotta, Tatangelo Fabiana, Bellosillo Beatriz, Veronese Silvio, Budillon Alfredo, Montagut Clara, Racca Patrizia, Marsoni Silvia, Falcone Alfredo, Corcoran Ryan B, Di Nicolantonio Federica, Loupakis Fotios, Siena Salvatore, Sartore-Bianchi Andrea, Bardelli Alberto
Abstract excerpt
Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic samples. Genotyping of CRC tissue has inherent limitations; a tissue sample represents a single snapshot in time, and it is subjected to spatial selection bias owing to tumor heterogeneity. Repeated tissue samples are difficult to...
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