Article
Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017
Thierry Alain R, Pastor Brice, Jiang Zhi-Qin, Katsiampoura Anastasia D, Parseghian Christine, Loree Jonathan M, Overman Michael J, Sanchez Cynthia, Messaoudi Safia El, Ychou Marc, Kopetz Scott
Abstract excerpt
Purpose: Liquid biopsies allow the tracking of clonal dynamics and detection of mutations during treatment.Experimental Design: We evaluated under blinded conditions the ability of cell-free DNA (cfDNA) to detect RAS/BRAF mutations in the plasma of 42 metastatic colorectal cancer patients treated on a phase Ib/II trial of FOLFOX and dasatinib, with or without cetuximab.Results: Prior to treatment, sequencing of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.