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Article

POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies.

Gene - 15 Sept 2016

Nicolas Emmanuelle, Golemis Erica A, Arora Sanjeevani

Abstract excerpt

The evolutionarily conserved human polymerase delta (POLD1) gene encodes the large p125 subunit which provides the essential catalytic activities of polymerase δ (Polδ), mediated by 5'-3' DNA polymerase and 3'-5' exonuclease moieties. POLD1 associates with three smaller subunits (POLD2, POLD3, POLD4), which together with Replication Factor C and Proliferating Nuclear Cell Antigen constitute the polymerase...

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Source

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Identifiers

PMID: 27320729
DOI: 10.1016/j.gene.2016.06.031
PMCID: PMC4969162

Genes

POLD1
POLD2
POLD3
POLD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies.PMID 27320729Read ↗

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POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development.Semantic proximity Read ↗

DNA polymerase delta is required for early mammalian embryogenesis.Semantic proximity Read ↗

Regulation and Modulation of Human DNA Polymerase δ Activity and FunctionSemantic proximity Read ↗

Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancerSemantic proximity Read ↗

Identification of a novel mutation in the polymerase delta 1 (POLD1) gene in a lipodystrophic patient affected by mandibular hypoplasia, deafness, progeroid features (MDPL) syndrome.Semantic proximity Read ↗

Structural and functional impact of the POLD1 Ser605del variant in MDPL syndrome: insights from protein-protein interactions.Semantic proximity Read ↗

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