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WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer

2 Dec 2024

Abstract excerpt

Luminal breast cancer exhibits a high incidence of bone recurrence when metastasizing to distant organs. The mechanisms underlying the organotropism of luminal breast cancer cells remain unclear. In this study, we aimed to determine the role of WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)-PTEN (phosphatase and tensin homolog deleted on chromosome ten) interaction in bone tropism in luminal breast...

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PMID: 39622957
DOI: 10.1038/s41598-024-81541-5

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