Article
The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone.
The Journal of pathology - 1 May 2017
Bellanger Aurélie, Donini Caterina F, Vendrell Julie A, Lavaud Jonathan, Machuca-Gayet Irma, Ruel Maëva, Vollaire Julien, Grisard Evelyne, Győrffy Balázs, Bièche Ivan, Peyruchaud Olivier, Coll Jean-Luc, Treilleux Isabelle, Maguer-Satta Véronique, Josserand Véronique, Cohen Pascale A
Abstract excerpt
Bone metastasis affects >70% of patients with advanced breast cancer. However, the molecular mechanisms underlying this process remain unclear. On the basis of analysis of clinical datasets, and in vitro and in vivo experiments, we report that the ZNF217 oncogene is a crucial mediator and indicator of bone metastasis. Patients with high ZNF217 mRNA expression levels in primary breast tumours had a higher risk of...
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