Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation

16 Jul 2022

Abstract excerpt

Organotropism during cancer metastasis occurs frequently but the underlying mechanism remains poorly understood. Here, we show that lysosomal protein transmembrane 5 (LAPTM5) promotes lung-specific metastasis in renal cancer. LAPTM5 sustains self-renewal and cancer stem cell-like traits of renal cancer cells by blocking the function of lung-derived bone morphogenetic proteins (BMPs). Mechanistic investigations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clusterin in disease pathology
Share to Erythrocyte Function and Pathophysiology
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35842443
DOI: 10.1038/s41467-022-31783-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradationPMID 35842443Read ↗

HIF-1α/LAPTM5/STAT1 axis promotes the malignant progression of clear cell renal cell carcinomaSemantic proximity Read ↗

LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.Semantic proximity Read ↗

WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancerSemantic proximity Read ↗

HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.Semantic proximity Read ↗

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1Semantic proximity Read ↗

Centrosome clustering control in osteoclasts through CCR5-mediated signalingSemantic proximity Read ↗

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type IISemantic proximity Read ↗

Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.