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Article

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

21 Aug 2019

Abstract excerpt

The underlying mechanisms of breast cancer cells metastasizing to distant sites are complex and multifactorial. Bone sialoprotein (BSP) and αvβ3 integrin were reported to promote the metastatic progress of breast cancer cells, particularly metastasis to bone. Most theories presume that BSP promotes breast cancer metastasis by binding to αvβ3 integrin. Interestingly, we found the αvβ3 integrin decreased in BSP...

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PMID: 31432600
DOI: 10.1111/cas.14172

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