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Article

Bioinformatics pipeline to guide post-GWAS studies in Alzheimer's: A new catalogue of disease candidate short structural variants.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2023

Lutz Michael W, Chiba-Falek Ornit

Abstract excerpt

BACKGROUND: Short structural variants (SSVs), including insertions/deletions (indels), are common in the human genome and impact disease risk. The role of SSVs in late-onset Alzheimer's disease (LOAD) has been understudied. In this study, we developed a bioinformatics pipeline of SSVs within LOAD-genome-wide association study (GWAS) regions to prioritize regulatory SSVs based on the strength of their predicted...

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Identifiers

PMID: 37253165
DOI: 10.1002/alz.13168
PMCID: PMC10524333

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