Article
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.
Genome medicine - 17 May 2021
Wang Liuyang, Balmat Thomas J, Antonia Alejandro L, Constantine Florica J, Henao Ricardo, Burke Thomas W, Ingham Andy, McClain Micah T, Tsalik Ephraim L, Ko Emily R, Ginsburg Geoffrey S, DeLong Mark R, Shen Xiling, Woods Christopher W, Hauser Elizabeth R, Ko Dennis C
Abstract excerpt
BACKGROUND: While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation to pathophysiology remains an important challenge. Methods are needed to systematically bridge this crucial gap to facilitate experimental testing of hypotheses and translation to clinical utility. RESULTS:...
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