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Article

Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders.

Psychological medicine - 1 Nov 2024

Kendler Kenneth S, Henrik Ohlsson, Sundquist Jan, Sundquist Kristina

Abstract excerpt

BACKGROUND: Robust clinical indices of etiologic heterogeneity for psychiatric disorders are rare. We investigate whether age at onset (AAO) reflects genetic heterogeneity, utilizing Genetic Risk Ratios (GRR) derived from Family Genetic Risk Scores (FGRS). METHODS: We examined, in individuals born in Sweden 1940-2003, whether AAO for five primary disorders -- drug use disorder (DUD), alcohol use disorder (AUD),...

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Identifiers

PMID: 39618328
DOI: 10.1017/S0033291724002630
PMCID: PMC11650156

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