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Article

The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity.

Molecular psychiatry - 1 Mar 2025

Kendler Kenneth S, Ohlsson Henrik, Sundquist Jan, Sundquist Kristina

Abstract excerpt

We investigate whether number of episodes (NoEs) meaningfully reflect genetic risk and genetic heterogeneity for five primary disorders-Drug Use Disorder (DUD), Alcohol Use Disorder (AUD), Major Depression (MD), Bipolar Disorder (BD), and Schizophrenia (SZ) ascertained from Swedish population registries. We utilize Genetic Risk Ratios (GRR)-defined as the ratio of the genetic risk for secondary disorders to the...

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Identifiers

PMID: 39223278
DOI: 10.1038/s41380-024-02727-x
PMCID: PMC11835530

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