Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.

doi:10.1016/j.euroneuro.2010.04.001

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Article

Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2010

Manchia Mirko, Zai Clement C, Squassina Alessio, Vincent John B, De Luca Vincenzo, Kennedy James L

Abstract excerpt

Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and...

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PMID: 20452754
DOI: 10.1016/j.euroneuro.2010.04.001

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