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Chemistry and Biology of DNA Repair

2 Jul 2003

Abstract excerpt

Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-repair pathways that recognize lesions in DNA and remove them through a number of diverse reaction sequences. Defects in DNA-repair proteins are associated with several human hereditary syndromes, which show a marked predisposition to cancer. Although DNA repair is essential for a healthy cell, DNA-repair enzymes...

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PMID: 12851945
DOI: 10.1002/anie.200200523

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