Article
Gene expression study on peripheral blood identifies progranulin mutations.
Annals of neurology - 1 Jul 2008
Coppola Giovanni, Karydas Anna, Rademakers Rosa, Wang Qing, Baker Matt, Hutton Mike, Miller Bruce L, Geschwind Daniel H
Abstract excerpt
Peripheral blood is a readily available tissue source allowing relatively noninvasive screening for a host of medical conditions. We screened total-blood progranulin (PGRN) levels in 107 patients with neurodegenerative dementias and related conditions, and 36 control subjects, and report the following findings: (1) confirmation of high progranulin expression levels in peripheral blood; (2) two subjects with...
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