Article

The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis

2024-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of the conserved MRN complex (MRE11, RAD50, and NBS1) through genome-wide analysis of meiotic resection in mice with various MRN mutations, including several that cause chromosomal instability in humans. Meiotic DSBs form...

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Literature Corpus work: 9b91b143-cba3-5dd5-bee2-e7022ede0d45
DOI: 10.1101/2024.08.17.608390

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