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Article

Hepatic lipogenesis marked by GCKR-modulated triglycerides increases serum FGF21 in children/teens with obesity.

Diabetes, obesity & metabolism - 1 Feb 2025

Maffeis Claudio, Morandi Anita, Zusi Chiara, Olivieri Francesca, Fornari Elena, Cavarzere Paolo, Piona Claudia, Corradi Massimiliano, Emiliani Federica, Da Ros Alessandro, Berni Canani Roberto, Mantovani Alessandro, Targher Giovanni

Abstract excerpt

AIMS: Fibroblast growth factor 21 (FGF21) decreases hepatic lipogenesis in animal models, and FGF21 analogues decrease serum triglycerides (TG) in adults in phase-2 trials. On the other hand, serum FGF21 is associated with higher TG in observational studies of people with obesity, raising a sort of paradox. We tested the hypothesis that FGF21 is induced by TG in youth with obesity, as a compensatory mechanism....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39611214
DOI: 10.1111/dom.16081
PMCID: PMC11701186

Genes

FGF21
TG
GCKR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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