Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.

doi:10.1210/jc.2015-1587

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Article

Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.

The Journal of clinical endocrinology and metabolism - 1 Aug 2015

Santoro Nicola, Caprio Sonia, Pierpont Bridget, Van Name Michelle, Savoye Mary, Parks Elizabeth J

Abstract excerpt

OBJECTIVE: This study's aim was to evaluate whether the GCKR rs1260326 variant increases hepatic de novo lipogenesis (DNL). SETTING AND DESIGN: To test this hypothesis, 14 adolescents, seven homozygous for the common allele (CC) and seven homozygous for the risk allele (TT), underwent measurement of hepatic DNL during the fasting state and after consumption of a carbohydrate (CHO) drink (75 g glucose and 25 g...

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Identifiers

PMID: 26043229
DOI: 10.1210/jc.2015-1587
PMCID: PMC4524990

Genes

GCKR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.PMID 26043229Read ↗

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