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Article

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.

Metabolism: clinical and experimental - 1 Dec 2022

Larsson Susanna C, Michaëlsson Karl, Mola-Caminal Marina, Höijer Jonas, Mantzoros Christos S

Abstract excerpt

BACKGROUND: Fibroblast growth factor 21 (FGF21) is a hepatokine that produces metabolic benefits, such as improvements of lipid profile. We performed a genome-wide association study (GWAS) to identify genetic variants associated with circulating FGF21 and investigated the causal effects of FGF21 on pertinent outcomes using Mendelian randomization (MR). METHODS: We conducted a GWAS testing ∼7.8 million DNA...

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Identifiers

PMID: 36208799
DOI: 10.1016/j.metabol.2022.155329

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