Article
An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels.
Diabetes - 1 Jun 2017
Cheung Chloe Y Y, Tang Clara S, Xu Aimin, Lee Chi-Ho, Au Ka-Wing, Xu Lin, Fong Carol H Y, Kwok Kelvin H M, Chow Wing-Sun, Woo Yu-Cho, Yuen Michele M A, Cherny Stacey S, Hai JoJo, Cheung Bernard M Y, Tan Kathryn C B, Lam Tai-Hing, Tse Hung-Fat, Sham Pak-Chung, Lam Karen S L
Abstract excerpt
Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to detect genetic determinants influencing circulating FGF21 levels. Single-variant association analysis...
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