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Article

Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study

10 Jun 2023

Abstract excerpt

Background Fibroblast growth factor 21 (FGF21) has demonstrated efficacy for reducing liver fat and reversing non-alcoholic steatohepatitis in phase 2 clinical trials. It is also postulated to have anti-fibrotic effects and therefore may be amenable to repurposing for the prevention and treatment of chronic kidney disease (CKD). Methods We leverage a missense genetic variant, rs739320 in the FGF21 gene, that...

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PMID: 37302695
DOI: 10.1016/j.metabol.2023.155616

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