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Article

FGF21 signalling pathway and metabolic traits - genetic association analysis.

European journal of human genetics : EJHG - 1 Dec 2010

Kaess Bernhard M, Barnes Timothy A, Stark Klaus, Charchar Fadi J, Waterworth Dawn, Song Kijoung, Wang William Y S, Vollenweider Peter, Waeber Gerard, Mooser Vincent, Zukowska-Szczechowska Ewa, Samani Nilesh J, Hengstenberg Christian, Tomaszewski Maciej

Abstract excerpt

Fibroblast growth factor 21 (FGF21) is a novel master regulator of metabolic profile. The biological actions of FGF21 are elicited upon its klotho beta (KLB)-facilitated binding to FGF receptor 1 (FGFR1), FGFR2 and FGFR3. We hypothesised that common polymorphisms in the FGF21 signalling pathway may be associated with metabolic risk. At the screening stage, we examined associations between 63 common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metabolic Networks and Pathways

Share to Quantitative Trait, Heritable

Share to Receptor, Fibroblast Growth Factor, Type 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 20717167
DOI: 10.1038/ejhg.2010.130
PMCID: PMC2988092

Genes

FGF21
FGFR2
KLB
FGFR1
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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