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Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

2025-11-17

Abstract excerpt

<h4>Introduction</h4> Alcohol use disorder (AUD) represents a tremendous societal burden, yet few efficacious therapies are available and widely used. Pre-clinical and human observational data support fibroblast growth factor 21 (FGF21) as a promising therapeutic target for the treatment of AUD. Here, we identify a robust genetic instrument for FGF21 agonism and leverage it in the Mendelian randomization paradigm...

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Literature Corpus work
f8196911-ccae-5c7c-b287-efd63de06d19
DOI
10.1101/2025.11.15.25340305
Open publication

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Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behavioursDOI 10.1101/2025.11.15.25340305
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