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Article

Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction.

Nature communications - 28 Nov 2024

Zhu Xin-Xin, Zheng Wen-Qing, Xia Zi-Wei, Chen Xin-Ru, Jin Tian, Ding Xu-Wei, Chen Fei-Fei, Chen Qi, Xu Jian-He, Kong Xu-Dong, Zheng Gao-Wei

Abstract excerpt

The stereoselectivity of enzymes plays a central role in asymmetric biocatalytic reactions, but there remains a dearth of evolution-driven biochemistry studies investigating the evolutionary trajectory of this vital property. Imine reductases (IREDs) are one such enzyme that possesses excellent stereoselectivity, and stereocomplementary members are pervasive in the family. However, the regulatory mechanism behind...

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PMID: 39609402
DOI: 10.1038/s41467-024-54613-3
PMCID: PMC11605051

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