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Article

Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326.

The Journal of biological chemistry - 1 Jan 2025

Georgieva Maria, Stojceski Filip, Wüthrich Fabian, Sosthène Carole, Blanco Pérez Laura, Grasso Gianvito, Jacquier Nicolas

Abstract excerpt

Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics against antibiotic-resistant pathogens. TAT-RasGAP317-326 is an AMP with broad range antibacterial activity, but its mechanism of action is unknown. In this study, we analyzed a strain of Escherichia coli with extensive resistance to TAT-RasGAP317-326 but not to other AMPs that we obtained after twenty passages during an in vitro...

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Identifiers

PMID: 39608713
DOI: 10.1016/j.jbc.2024.108018
PMCID: PMC11842939

Genes

TAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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