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In vitro resistance selection in <i>Acinetobacter baumannii</i> against the antimicrobial peptide TAT-RasGAP <sub>317-326</sub> can cause cross-resistance to polymyxins through mutations in <i>pmrAB</i>

2025-01-22

Abstract excerpt

Antibiotic resistance is a growing public health concern. In this context, there is an urgent need of alternative antimicrobial agents effective towards multidrug-resistant bacteria. Antimicrobial peptides (AMPs) are naturally occurring peptides, part of the first antimicrobial line of defence of a wide variety of organisms. AMPs were identified as a promising alternative to classical antibiotics with a low potent...

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Literature Corpus work
1fc48b68-8cdc-500f-b21e-edbabf700e7d
DOI
10.1101/2025.01.22.634246
Open publication

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In vitro resistance selection in <i>Acinetobacter baumannii</i> against the antimicrobial peptide TAT-RasGAP <sub>317-326</sub> can cause cross-resistance to polymyxins through mutations in <i>pmrAB</i>DOI 10.1101/2025.01.22.634246
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