Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

Abstract excerpt

Introduction Cystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet, considered as one important factor contributing to its colonization by opportunistic pathogens such as Pseudomonas aeruginosa . However, in recent years evidence was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial biofilms and quorum sensing
• Share to Cystic Fibrosis Research Advances
• Share to Neonatal Respiratory Health Research