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Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines

25 Mar 2024

Abstract excerpt

transcribed mRNA found in most current RNA vaccines, saRNA or taRNA can be massively replicated within cells in the presence of RNA-amplifying enzymes known as replicases. We recently demonstrated that this property could enhance immune responses with minimal injected RNA amounts. In saRNA-based vaccines, replicase and antigens are encoded on the same mRNA molecule, resulting in very long RNA sequences, which...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Viral gastroenteritis research and epidemiology

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PMID: 38675846
DOI: 10.3390/v16040503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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