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Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus

24 Dec 2015

Abstract excerpt

Reoviruses are non-enveloped viruses with a segmented double stranded RNA genome. In humans, they are not associated with serious disease. Human reoviruses exhibit an inherent preference to replicate in tumor cells, which makes them ideally suited for use in oncolytic virotherapies. Their use as anti-cancer agent has been evaluated in several clinical trials, which revealed that intra-tumoral and systemic...

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PMID: 26712782
DOI: 10.3390/v8010004

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