Article
Genomic and Phenotypic Variations Among Thai-53 and Mycobacterium leprae Clinical Isolates: Implications for Leprosy Pathogenesis and Research.
Pathogens (Basel, Switzerland) - 12 Nov 2024
Gomes Tiago Araujo, da Silva Tatiana Pereira, Machado Edson, Vasconcelos Sidra Ezidio Gonçalves, Mietto Bruno Siqueira, de Faria Bertoluci Daniela Ferreira, Rosa Patricia Sammarco, Pinheiro Roberta Olmo, Suffys Philip Noel, Lery Letícia Miranda Santos, Lara Flavio Alves
Abstract excerpt
Throughout Mycobacterium leprae's (M. leprae) evolutionary trajectory, nearly half of its genome was converted into pseudogenes. Despite this drastic reduction in genetic content, the genome sequence identity among M. leprae isolates worldwide is remarkably high compared to other pathogens. In this study, we investigated the genotype and morphotype of three M. leprae strains: the reference strain Thai-53...
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