Article
Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015
Singh Pushpendra, Benjak Andrej, Schuenemann Verena J, Herbig Alexander, Avanzi Charlotte, Busso Philippe, Nieselt Kay, Krause Johannes, Vera-Cabrera Lucio, Cole Stewart T
Abstract excerpt
Mycobacterium lepromatosis is an uncultured human pathogen associated with diffuse lepromatous leprosy and a reactional state known as Lucio's phenomenon. By using deep sequencing with and without DNA enrichment, we obtained the near-complete genome sequence of M. lepromatosis present in a skin biopsy from a Mexican patient, and compared it with that of Mycobacterium leprae, which has undergone extensive...
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