Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

doi:10.1038/ng.477

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Article

Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

Nature genetics - 1 Dec 2009

Monot Marc, Honoré Nadine, Garnier Thierry, Zidane Nora, Sherafi Diana, Paniz-Mondolfi Alberto, Matsuoka Masanori, Taylor G Michael, Donoghue Helen D, Bouwman Abi, Mays Simon, Watson Claire, Lockwood Diana, Khamesipour Ali, Khamispour Ali, Dowlati Yahya, Jianping Shen, Rea Thomas H, Vera-Cabrera Lucio, Stefani Mariane M, Banu Sayera, Macdonald Murdo, Sapkota Bishwa Raj, Spencer John S, Thomas Jérôme, Harshman Keith, Singh Pushpendra, Busso Philippe, Gattiker Alexandre, Rougemont Jacques, Brennan Patrick J, Cole Stewart T

Abstract excerpt

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x...

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PMID: 19881526
DOI: 10.1038/ng.477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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