Article
Use of 3' Rapid Amplification of cDNA Ends (3' RACE)-Based Targeted RNA Sequencing for Profiling of Druggable Genetic Alterations in Urothelial Carcinomas.
International journal of molecular sciences - 12 Nov 2024
Mitiushkina Natalia V, Tiurin Vladislav I, Anuskina Aleksandra A, Bordovskaya Natalia A, Nalivalkina Ekaterina A, Terina Darya M, Berkut Mariya V, Shestakova Anna D, Syomina Maria V, Kuligina Ekaterina Sh, Togo Alexandr V, Imyanitov Evgeny N
Abstract excerpt
Targeted treatment of advanced or metastatic urothelial carcinomas (UCs) requires the identification of druggable mutations. This study describes the development of a 3' Rapid Amplification of cDNA Ends (3' RACE)-based targeted RNA sequencing panel which accounts for the status of all genes relevant to UC treatment, namely, FGFR1-4, KRAS, NRAS, BRAF, ERBB2 (HER2), CD274 (PD-L1) and PIK3CA. FGFR2/3-activating...
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