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Clonal hematopoiesis is clonally unrelated to multiple myeloma and is associated with specific microenvironmental changes

20 Mar 2025

Abstract excerpt

ABSTRACT: Multiple myeloma (MM) initiation is dictated by genomic events. However, its progression from asymptomatic stages to an aggressive disease that ultimately fails to respond to treatments is also dependent on changes of the tumor microenvironment (TME). Clonal hematopoiesis of indeterminate potential (CHIP) is a prevalent clonal condition of the hematopoietic stem cell whose presence is causally linked to...

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PMID: 40112284
DOI: 10.1182/blood.2024026236

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