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Article

Single-Cell DNA Sequencing Reveals an Evolutionary Pattern of CHIP in Transplant Eligible Multiple Myeloma Patients.

Cells - 9 Apr 2024

Borsi Enrica, Vigliotta Ilaria, Poletti Andrea, Mazzocchetti Gaia, Solli Vincenza, Zazzeroni Luca, Martello Marina, Armuzzi Silvia, Taurisano Barbara, Kanapari Ajsi, Pistis Ignazia, Zamagni Elena, Pantani Lucia, Rocchi Serena, Mancuso Katia, Tacchetti Paola, Rizzello Ilaria, Rizzi Simonetta, Dan Elisa, Sinigaglia Barbara, Cavo Michele, Terragna Carolina

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the phenomenon where a hematopoietic stem cell acquires fitness-increasing mutation(s), resulting in its clonal expansion. CHIP is frequently observed in multiple myeloma (MM) patients, and it is associated with a worse outcome. High-throughput amplicon-based single-cell DNA sequencing was performed on circulating CD34+ cells collected from twelve...

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Identifiers

PMID: 38667272
DOI: 10.3390/cells13080657
PMCID: PMC11049155

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