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Genome‐wide methylation profiling of maternal cell‐free DNA using methylated DNA sequencing ( MeD ‐seq) indicates a placental and immune‐cell signature

26 Nov 2024

Abstract excerpt

BACKGROUND: Placental-originated cell-free DNA (cfDNA) provides unique opportunities to study (epi)genetic placental programming remotely, but studies investigating the cfDNA methylome are scarce and usually technologically challenging. Methylated DNA sequencing (MeD-seq) is well compatible with low cfDNA concentrations and has a high genome-wide coverage. We therefore aim to investigate the feasibility of...

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PMID: 39589853
DOI: 10.1111/eci.14363

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