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Hypertensive disorders of pregnancy share common cfDNA methylation profiles

18 Nov 2022

Abstract excerpt

Hypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these vascular disorders. In early pregnancy, epigenetic changes using cell free DNA (cfDNA) are largely unexplored. We aimed to investigate these in HDP between 11 and 14 weeks of gestation by analysis of cfDNA methylation profiles in...

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PMID: 36400896
DOI: 10.1038/s41598-022-24348-6

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