Article

Distinct DNA Methylation Signatures in Maternal Blood Reveal Unique Immune Cell Shifts in Preeclampsia and the Pregnancy-Postpartum Transition

2024-12-18

Abstract excerpt

1.0 Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by immune dysregulation and significant risks to maternal and fetal health. While current management relies on high-risk patient monitoring and early diagnosis, these methods are costly and burdensome, especially for low-risk pregnancies. There is a pressing need for non-invasive tools to predict and monitor PE. DNA methylation (DNAm) is a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fd7a5e8-38d1-5a38-8bc6-245d5b3a78c6
DOI: 10.1101/2024.12.13.628167

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct DNA Methylation Signatures in Maternal Blood Reveal Unique Immune Cell Shifts in Preeclampsia and the Pregnancy-Postpartum TransitionDOI 10.1101/2024.12.13.628167Read

High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their childrenSemantic proximity Read

Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencingSemantic proximity Read

Characterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learningSemantic proximity Read

DNA Methylation as a Biomarker for PreeclampsiaSemantic proximity Read

Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancySemantic proximity Read

Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsiaSemantic proximity Read

Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes MellitusSemantic proximity Read

Cell-specific Characterization of the Placental MethylomeSemantic proximity Read

Cell-specific characterization of the placental methylomeSemantic proximity Read

An atlas of transcriptional dynamics in maternal blood over the course of healthy pregnancySemantic proximity Read

Molecular subtyping of hypertensive disorders of pregnancySemantic proximity Read

Mining DNA methylation alterations towards a classification of placental pathologiesSemantic proximity Read