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Profiling (placental) DNA methylation in cell-free DNA across gestation: the Rotterdam Periconception Cohort

1 Jan 2025

Abstract excerpt

Placental DNA methylation varies across gestation and is associated with obstetrical complications. Cell-free DNA (cfDNA) from maternal plasma could provide a noninvasive approach to study placental DNA methylation in ongoing pregnancies. However, research on maternal cfDNA methylation is limited and technologically challenging. Therefore, we aimed to investigate DNA methylation in maternal cfDNA and placental...

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PMID: 40338255
DOI: 10.1093/molehr/gaaf011

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