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Article

Disrupting the three-dimensional regulatory topology of the Pitx1 locus results in overtly normal development.

Development (Cambridge, England) - 9 Apr 2018

Sarro Richard, Kocher Acadia A, Emera Deena, Uebbing Severin, Dutrow Emily V, Weatherbee Scott D, Nottoli Timothy, Noonan James P

Abstract excerpt

Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers. However, identifying enhancers essential for the expression of their target genes has proven challenging. Maps of long-range regulatory interactions may provide the means to identify enhancers crucial for developmental gene expression. To investigate this hypothesis, we used circular chromosome...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to In Situ Hybridization

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Source

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Identifiers

PMID: 29549111
DOI: 10.1242/dev.158550
PMCID: PMC5963865

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