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PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense

22 Nov 2024

Abstract excerpt

LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens, but the molecular mechanism for LAP activation is still unclear. Here, we find programmed cell death 6 (PDCD6) as a negative regulator of LAP. PDCD6 deficiency in mice and macrophages induces enhanced bactericidal activity and LAP formation. In parallel, lactate dehydrogenase A (LDHA) activity and lactate production is...

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PMID: 39578445
DOI: 10.1038/s41467-024-54377-w

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