Article
The struggle of a good friend getting old: cellular senescence in viral responses and therapy.
EMBO reports - 7 Apr 2021
Kohli Jaskaren, Veenstra Iris, Demaria Marco
Abstract excerpt
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of pro-inflammatory cytokines and molecules. Senescence-associated phenotypes restrict damage propagation and activate immune responses, two essential processes involved in response to viral infections. However, excessive accumulation and persistence of senescent cells can become detrimental and...
Topics
- Aging
- Cell Cycle Checkpoints
- Cellular Senescence
- Cytokines
- Friends
- Humans
- Phenotype