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Article

A landscape of genetic heterogeneity in germline predisposition to familial chronic lymphocytic leukemia

2025-09-01

Abstract excerpt

<title>Abstract</title> <p>This study provides a comprehensive analysis of the germline landscape in 81 families with chronic lymphocytic leukemia (CLL). We uncovered key genetic pathways associated with CLL predisposition, including telomere maintenance, DNA double-strand break (DSB) repair, and immune regulation. Notably, pathogenic variants were found in <italic>POT1</italic> and <italic>TINF2</italic>, sugges...

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Literature Corpus work
7d5ca7d9-43f0-5f46-ac60-611160a497b9
DOI
10.21203/rs.3.rs-7313089/v1
Open publication

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A landscape of genetic heterogeneity in germline predisposition to familial chronic lymphocytic leukemiaDOI 10.21203/rs.3.rs-7313089/v1
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