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Liver X receptor unlinks intestinal regeneration and tumorigenesis

20 Nov 2024

Abstract excerpt

Abstract Uncontrolled regeneration leads to neoplastic transformation1–3. The intestinal epithelium requires precise regulation during continuous homeostatic and damage-induced tissue renewal to prevent neoplastic transformation, suggesting that pathways unlinking tumour growth from regenerative processes must exist. Here, by mining RNA-sequencing datasets from two intestinal damage models4,5 and using...

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PMID: 39567700
DOI: 10.1038/s41586-024-08247-6

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