Article
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2021
Heuberger Julian, Grinat Johanna, Kosel Frauke, Liu Lichao, Kunz Séverine, Vidal Ramon Oliveira, Keil Marlen, Haybaeck Johannes, Robine Sylvie, Louvard Daniel, Regenbrecht Christian, Sporbert Anje, Sauer Sascha, von Eyss Björn, Sigal Michael, Birchmeier Walter
Abstract excerpt
Specified intestinal epithelial cells reprogram and contribute to the regeneration and renewal of the epithelium upon injury. Mutations that deregulate such renewal processes may contribute to tumorigenesis. Using intestinal organoids, we show that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which is associated with increased levels of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.