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Article

Phenotypic landscape of intestinal organoid regeneration.

Nature - 1 Oct 2020

Lukonin Ilya, Serra Denise, Challet Meylan Ludivine, Volkmann Katrin, Baaten Janine, Zhao Rui, Meeusen Shelly, Colman Karyn, Maurer Francisca, Stadler Michael B, Jenkins Jeremy, Liberali Prisca

Abstract excerpt

The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium1,2. Here we unravel the mechanisms that orchestrate both organoid formation and the regeneration of intestinal tissue, using an image-based screen to assay an annotated library of compounds. We generate multivariate feature profiles for hundreds of thousands...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33029001
DOI: 10.1038/s41586-020-2776-9
PMCID: PMC7116869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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