Wild-Type Domestication: Loss of Intrinsic Metabolic Traits Concealed by Culture in Rich Media.

Abstract excerpt

Bacteria are typically isolated on rich media to maximise isolation success, removing them from their native evolutionary context. This eliminates selection pressures, enabling otherwise deleterious genomic events to accumulate. Here, we present a cautionary tale of these 'quiet mutations' which can persist unnoticed in bacterial culture lines. We used a combination of microbiological culture (standard and...

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