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Article

Genetically predicted circulating linoleic acid levels and risk of osteoarthritis: a two-sample mendelian randomization study.

BMC musculoskeletal disorders - 13 Nov 2024

Yang Wen, Xiao Wenwu, Liu Hailong

Abstract excerpt

OBJECTIVES: This study aimed to provide insight into the effect of genetically predicted linoleic acid (LA) levels on osteoarthritis (OA). METHODS: The LA dataset was obtained from the UK Biobank (UKBB) consortium and contained 114,999 samples. The OA discovery dataset was derived from MRC-IEU consortium and included 38,472 cases and 424,461 controls. The OA validation set was derived from a summary-level...

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Case-Control Studies
Genome-Wide Association Study
Linoleic Acid
Mendelian Randomization Analysis
Osteoarthritis

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PMID: 39563274
DOI: 10.1186/s12891-024-08018-4
PMCID: PMC11577923

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